Office: Scott Hall 4N201
Phone: (412) 268-3955

Department Head
Professor Bin He
bhe1@andrew.cmu.edu

Associate Department Head for Undergraduate Education
Professor Conrad M. Zapanta
czapanta@cmu.edu

Associate Department Head for Graduate Education
Professor Keith Cook
keicook@andrew.cmu.edu
http://www.bme.cmu.edu/

Biomedical Engineering Overview

Biomedical engineering education at Carnegie Mellon University reflects the belief that a top biomedical engineer must be deeply trained in both a traditional engineering practice and biomedical sciences. The unique additional major program leverages extensive collaborations with sister departments in the College of Engineering and with major medical institutions in Pittsburgh. This collaborative approach, combined with a rigorous engineering education, confers unique depth and breadth to the education of Biomedical Engineering graduates.

Students who elect Biomedical Engineering as a major must also declare a major in one of the traditional engineering disciplines: Chemical Engineering, Civil & Environmental Engineering, Electrical & Computer Engineering, Materials Science & Engineering, or Mechanical Engineering.

The curriculum, demanding but readily feasible to complete in four years, is highly rewarding to motivated students.

Common Requirements for the Additional Major

The Biomedical Engineering additional major program takes advantage of curricular overlaps between Biomedical Engineering and traditional engineering majors, such that the dual major can be completed in four years with only a modest increase in course requirements. The requirements for Biomedical Engineering consist of the core, the tracks, and the capstone design course. The core exposes students to basic facets of biomedical engineering to lay a foundation. The tracks allow students to build depth in a specific aspect of biomedical engineering. The capstone design engages students in team work to develop real-world applications.

While most tracks are designed to parallel a traditional engineering discipline, a self-designed track allows students to pursue specific areas not covered by the pre-defined tracks. The additional major in Biomedical Engineering should be declared at the same time when declaring a traditional engineering major.

Course Requirements for the Additional Major

Minimum units required for additional major:93–102

Student majoring in Biomedical Engineering must meet three sets of requirements:  1) Biomedical Engineering (BME), 2) a traditional engineering discipline, and 3) College of Engineering General Education sequence.  The Quality Point Average (QPA) for courses that count toward the additional major must be 2.00 or better. No course taken on a pass/fail or audit basis may be counted toward the additional major. 

The course requirements for the BME portion of the additional major are as follows:

Core Courses (all required)

Units
03-121Modern Biology- Fall and Spring9
42-101Introduction to Biomedical Engineering- Fall and Spring12
42-201Professional Issues in Biomedical Engineering- Fall and Spring3
42-202Physiology- Fall and Spring9
42-203Biomedical Engineering Laboratory- Fall and Spring #9
42-302Biomedical Engineering Systems Modeling and Analysis- Fall and Spring9
42-401Foundation of BME Design-Fall*6
42-402BME Design Project- Spring9
 66

# Also known as 03-206 for Health Professions Program students.

* 42-401 serves as the precursor/pre-requisite for 42-402 BME Design Project.

Tracks (Completion of one track is required)

  • Biomaterials and Tissue Engineering (BMTE)
  • Biomechanics (BMEC)
  • Biomedical Signal and Image Processing (BSIP)
  • Cellular and Molecular Biotechnology (CMBT)
  • Self-Designed Biomedical Engineering (SBME)

Biomaterials and Tissue Engineering (BMTE) Track

Overview

The BMTE track addresses issues at the interface of materials science, biology and engineering. The topics include the interactions between materials and cells or tissues, the effects of such interactions on cells and tissues, the design of materials for biological applications, and the engineering of new tissues.

Targets

The BMTE track is ideal for students interested in combining the education of Biomedical Engineering with Materials Science & Engineering or with Chemical Engineering.  Both provide the necessary foundation in chemistry and/or materials science. Students of this track may develop careers in biotechnology, tissue engineering, biopharmaceuticals, and medical devices that leverage materials properties.

Requirements

In addition to the Biomedical Engineering core courses, students in the BMTE Track must take the following combination of three courses:

  • One (1) Required BMTE elective
  • Two (2) BMTE Electives (either Required or Additional

BMTE Electives

Required BMTE Electives (must take one of the following)
42/27-411Engineering Biomaterials- Fall9
42-612/27-520Tissue Engineering- Spring12
42-670Special Topics: Biomaterial Host Interactions in Regenerative Medicine- Fall12

Additional BMTE Electives
03-320Cell Biology9
42-613Molecular and Micro-scale Polymeric Biomaterials in Medicine- Spring9
42-620Engineering Molecular Cell Biology- Fall12
42-624Biological Transport and Drug Delivery- Spring9
42-673Special Topics: Stem Cell Engineering- Fall, every other year9
42-772Special Topics: Applied Nanoscience and Nanotechnology- Fall12
42-x00BME Research* or 39-500 Honors Research Project* or 42-661 Surgery for Engineers or 42-671 Precision Medicine for Biomedical Engineers9

* The 42-x00 research project (42-200/300/400 Sophomore/Junior/Senior Biomedical Engineering Research Project OR 39-500 Honors Research Project) must be on a BME topic that is aligned to the track, supervised or co-supervised by a BME faculty member, and conducted for 9 or more units of credit. 

Some Special Topics and newly offered or intermittently offered courses may be acceptable as BMTE track electives. Students should consult with their BME advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as BMTE track electives.

Sample schedules can be found on the BMTE page on the BME website.

Biomechanics (BMEC) Track

Overview

The BMEC track addresses the application of solid or fluid mechanics to biological and medical systems. It provides quantitative understanding of the mechanical behavior of molecules, cells, tissues, organs, and whole organisms. The field has seen a wide range of applications from the optimization of tissue regeneration to the design of surgical and rehabilitation devices. 

Targets

The BMEC track is ideally suited to the combined education of Biomedical Engineering and Mechanical Engineering or Civil & Environmental Engineering.  Both provide the necessary foundation in the underlying physical principles and their non-Biomedical Engineering applications. This track may also appeal to students of Electrical & Computer Engineering who are interested in biomedical robotics. Education in biomechanics enables students to pursue careers in medical devices or rehabilitation engineering.

Requirements

In addition to the Biomedical Engineering core courses, students in the BMEC Track must take must take the following combination of three courses:

  • One (1) Required BMEC Elective
  • Two (2) BMEC Electives (either Required or Additional)

BMEC Electives

Required BMEC Electives (must take at least one of the following)
42-341Introduction to Biomechanics- Spring9
42-645/24-655Cellular Biomechanics- Intermittent9
42-646Molecular Biomechanics- Intermittent9
42-648Cardiovascular Mechanics- Intermittent12

Additional BMEC Electives
33-441/03-439Introduction to BioPhysics- Fall10
42-444Medical Devices- Fall and Spring9
42-447Rehabilitation Engineering- Fall9
42-640/24-658Image-Based Computational Modeling and Analysis- Spring12
42-643Microfluids- Intermittent12
42-647Continuum Biomechanics: Solid and Fluid Mechanics of Physiological Systems12
42-x00BME Research* or 39-500 Honors Research Project* or 42-661 Surgery for Engineers or 42-671 Precision Medicine for Biomedical Engineers

* The 42-x00 research project (42-200/300/400 Sophomore/Junior/Senior Biomedical Engineering Research Project OR 39-500 Honors Research Project) must be on a BME topic that is aligned to the track, supervised or co-supervised by a BME faculty member, and conducted for 9 or more units of credit. 

Some Special Topics, newly offered or intermittently offered courses may be acceptable as track electives.  Students should consult with their advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as track electives.

Sample schedules can be found on the BMEC page on the BME website.

Biomedical Signal and Image Processing (BSIP) Track

Overview

The BSIP track addresses bio/medical phenomena based on the information embedded in sensor-detected signals, including digital images and nerve electrical pulses. Students in this track will gain understanding of the technologies involved in acquiring signals and images, the mathematical principles underlying the processing and analysis of signals, and the applications of signal/image processing methods in basic research and medicine.

Targets

This track aligns most naturally with a combined education of Biomedical Engineering and Electrical & Computer Engineering, which lays a solid foundation in signal processing principles. This track prepares students for careers in medical imaging or smart prosthetics. It also interfaces with many clinical practices including radiology, neurology/neurosurgery, and pathology.

Requirements

In addition to the Biomedical Engineering core courses, students in the BSIP Track must take the following combination of three courses:

  • One (1) Required BSIP elective
  • Two (2) BSIP Electives (either Required or Additional)

BSIP Electives

Required BSIP Electives (must take at least one of the following)
42-630Introduction to Neuroscience for Engineers- Spring12
42-631Neural Data Analysis- Fall9
42-632Neural Signal Processing- Spring12
42-672Fundamentals of Biomedical Imaging and Image Analysis- Spring12
Additional BSIP Electives
03-534Biological Imaging and Fluorescence Spectroscopy- Spring9
15-386Neural Computation- Spring9
16-725Medical Image Analysis- Spring12
18-491Fundamentals of Signal Processing- Fall 112
or 18-792 Advanced Digital Signal Processing
42-426Biosensors and BioMEMS- Intermittent9
42-447Rehabilitation Engineering- Fall9
42-474Special Topics: Introduction to Biophotonics9
42-640/24-658Image-Based Computational Modeling and Analysis- Spring12
42-698Special Topics- A : Bioinstrumentation - Intermittent9
42-x00BME Research* or 39-500 Honors Research Project* or 42-661 Surgery for Engineers or 42-671 Precision Medicine for Biomedical Engineers

1 Note that either 18-491 or 18-792 (offered in Spring), but not both, may be counted as a BSIP Elective.

* The 42-x00 research project (42-200/300/400 Sophomore/Junior/Senior Biomedical Engineering Research Project OR 39-500 Honors Research Project) must be on a BME topic that is aligned to the track, supervised or co-supervised by a BME faculty member, and conducted for 9 or more units of credit. 

Some Special Topics, newly offered or intermittently offered courses may be acceptable as track electives.  Students should consult with their advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as track electives.

Sample schedules can be found on the BSIP page on the BME website.

Cellular and Molecular Biotechnology (CMBT) Track

Overview

The CMBT track emphasizes fundamentals and applications of biochemistry, biophysics, and cell biology, and processes on the nanometer to micrometer size scale. Students in this track acquire understanding of the molecular and cellular bases of life processes, and build skills in quantitative modeling of live cell-based biotechnologies and in technologies that exploit the unique properties of biomolecules in non-biological settings.

Targets

The CMBT track is ideally suited for the combined education of Biomedical Engineering and Chemical Engineering, which provides a strong core of chemistry and molecular processing principles. The track may also interest students of Mechanical Engineering, Materials Science & Engineering, or Civil & Environmental Engineering who have an interest in molecular aspects of Biomedical Engineering. The CMBT track prepares students for careers in bio/pharmaceutical, medical diagnostics, biosensors, drug delivery, and biological aspects of environmental engineering.

Requirements

In addition to the Biomedical Engineering core courses, students in the CMBT Track must take the following combination of three courses:

  • One (1) Required CMBT Elective
  • Two (2) CMBT Electives (either Required or Additional)

CMBT Electives

Required CMBT Electives (must take at least one of the following)
42-620Engineering Molecular Cell Biology- Fall12
42-623Cellular and Molecular Biotechnology- Intermittent9
42-624Biological Transport and Drug Delivery- Spring9
Additional CMBT Electives
03-320Cell Biology9
42/06-622Bioprocess Design- Spring, intermittent9
42-643Microfluids- Spring, intermittent12
42-645/24-655Cellular Biomechanics- Intermittent9
42-646Molecular Biomechanics- Spring, every other year9
42-673Special Topics: Stem Cell Engineering- Fall, every other year9
42-772Special Topics: Applied Nanoscience and Nanotechnology- Fall12
42-x00BME Research* or 39-500 Honors Research Project* or 42-661 Surgery for Engineers or 42-671 Precision Medicine for Biomedical Engineers

* The 42-x00 research project (42-200/300/400 Sophomore/Junior/Senior Biomedical Engineering Research Project OR 39-500 Honors Research Project) must be on a BME topic that is aligned to the track, supervised or co-supervised by a BME faculty member, and conducted for 9 or more units of credit. 

Some Special Topics, newly offered or intermittently offered courses may be acceptable as track electives.  Students should consult with their advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as track electives.

Sample schedules can be found on the CMBT page on the BME website.

Self-Designed Biomedical Engineering (SBME) Track

The SBME track is aimed at helping highly motivated students who have a strong sense of career direction that falls beyond the scope of regular Biomedical Engineering tracks, and allows students to choose courses relevant to the theme from across the University.  Students are allowed to design the "track" portion of the curriculum in consultation with the faculty.  Example themes include medical robotics, neural engineering, or computational biomedical engineering.  

Requirements

In addition to the Biomedical Engineering core requirements, students must take three elective courses of at least 9 units each. These elective courses must form a coherent theme that is relevant to biomedical engineering. In addition, at least one of the elective courses must be judged by the Biomedical Engineering Undergraduate Affairs Committee to have substantial biological or medical content.

If undergraduate research is part of the SBME track, the research project must be on a BME topic that is aligned to the track, supervised or co-supervised by a BME faculty member, and conducted for 9 or more units of credit. 

Petition Procedure

  1. Students wishing to pursue a self-designed track should first consult with the Biomedical Engineering Undergraduate Affairs Committee. Contacts for the Committee are Prof. Robert Tilton (committee chair), and Prof. Conrad Zapanta (Biomedical Engineering Associate Head).
  2. A SBME track proposal must be submitted electronically as a Word document to Prof. Conrad Zapanta at least three weeks prior to Pre-Registration during the spring of the sophomore year. The proposal must include:
    • The three courses of the designed track, including catalog descriptions and when these courses are expected to be taken.
    • A justification of how these courses form a coherent theme relevant to biomedical engineering.
    • Two alternative courses that may substitute for one of the proposed courses, in case the original course is not available.
  3. Once approved, the student must sign an agreement listing the theme and the three courses comprising the SBME track.
  4. In the event that issues beyond the student's control, such as course scheduling or cancellation, prevent the student from completing the approved course plan, the student must do one of the following:
    • Petition the Biomedical Engineering Undergraduate Affairs Committee to substitute a course with another course that fits the approved theme, OR
    • Complete one of the regular tracks

Minor in Biomedical Engineering

Associate Department Head of Undergraduate Education

Professor Conrad M. Zapanta
czapanta@cmu.edu
http://www.bme.cmu.edu/

The minor program is designed for engineering students who desire exposure to biomedical engineering but may not have the time to pursue the Biomedical Engineering additional major. The program is also open to students of all colleges and is popular among science majors. In conjunction with other relevant courses, the program may provide a sufficient background for jobs or graduate studies in biomedical engineering. Students interested in a medical career may also find this program helpful.

The Biomedical Engineering minor curriculum is comprised of three core courses and three electives. Students pursuing the minor may contact BME Associate Head for Undergraduate Education for advice. Students interested in declaring Biomedical Engineering minor should contact either the Associate Department Head for Undergraduate Education or the Biomedical Engineering Undergraduate Program Advisor.

Requirements

Minimum units required for minor:57
03-121Modern Biology9
42-101Introduction to Biomedical Engineering
(co-req. or pre-req. 03-121)
12
42-202Physiology
(pre-req. 03-121 or permission of instructor)
9
42-xxxBME Elective (>= 9 units), Any course offered by the Department of Biomedical Engineering numbered 42-300 or higher and worth at least 9 units
xx-xxxElective I (>= 9 units) #
xx-xxxElective II (>= 9 units) +

Some Special Topics, newly offered or intermittently offered 42-xxx may be acceptable as electives.  Students should consult with their advisors and petition the Biomedical Engineering Undergraduate Affairs Committee for permission to include such courses.

Notes

Course Descriptions

Note on Course Numbers

Each Carnegie Mellon course number begins with a two-digit prefix which designates the department offering the course (76-xxx courses are offered by the Department of English, etc.). Although each department maintains its own course numbering practices, typically the first digit after the prefix indicates the class level: xx-1xx courses are freshmen-level, xx-2xx courses are sophomore level, etc. xx-6xx courses may be either undergraduate senior-level or graduate-level, depending on the department. xx-7xx courses and higher are graduate-level. Please consult the Schedule of Classes each semester for course offerings and for any necessary pre-requisites or co-requisites.

42-101 Introduction to Biomedical Engineering
Fall and Spring: 12 units
This course will provide exposure to basic biology and engineering problems associated with living systems and health care delivery. Examples will be used to illustrate how basic concepts and tools of science & engineering can be brought to bear in understanding, mimicking and utilizing biological processes. The course will focus on four areas: biotechnology, biomechanics, biomaterials and tissue engineering and biosignal and image processing and will introduce the basic life sciences and engineering concepts associated with these topics. Pre-requisite OR co-requisite: 03-121 Modern Biology.
42-200 Sophomore BME Research Project
Fall and Spring
Research projects for sophomores under the direction of a regular or adjunct BME faculty member. Arrangements may also be made via the Associate Head of BME for off-campus projects provided that a regular or adjunct BME faculty member agrees to serve as a co-advisor. The nature of the project, the number of units, and the criteria for grading are to be determined between the student and the research advisor. The agreement should be summarized in a two-page project description with sign-off by the research advisor and a copy submitted for review and filing with the BME Department. A final written report of the results is required. Units may vary from 9 to 12 according to the expected time commitment, with one unit corresponding to 1 hour of research per week. One (but not more than one) semester of research, if registered for at least 9 units, may be counted as a restricted elective course toward the BME additional major.
42-201 Professional Issues in Biomedical Engineering
Fall and Spring: 3 units
This course exposes students to many of the issues that biomedical engineers face. It provides an overview of professional topics including bioethics, regulatory issues, communication skills, teamwork, and other contemporary issues. Outside speakers and case studies will describe real world problems and professional issues in biotechnology and bioengineering, and progress toward their solution. Prerequisite or co-requisite: 42-101 Introduction to Biomedical Engineering
42-202 Physiology
Fall and Spring: 9 units
This course is an introduction to human physiology and includes units on all major organ systems. Particular emphasis is given to the musculoskeletal, cardiovascular, respiratory, digestive, excretory, and endocrine systems. Modules on molecular physiology tissue engineering and physiological modeling are also included. Due to the close interrelationship between structure and function in biological systems, each functional topic will be introduced through a brief exploration of anatomical structure. Basic physical laws and principles will be explored as they relate to physiologic function. Prerequisite or co-requisite: 03-121 Modern Biology, or permission of instructor.
42-203 Biomedical Engineering Laboratory
Fall and Spring: 9 units
This laboratory course is designed to provide students with the ability to make measurements on and interpret data from living systems. The experimental modules reinforce concepts from 42-101 Introduction to Biomedical Engineering and expose students to four areas of biomedical engineering: biomedical signal and image processing, biomaterials, biomechanics, and cellular and molecular biotechnology. Several cross-cutting modules are included as well. The course includes weekly lectures to complement the experimental component. Prerequisites: 42-101 Introduction to Biomedical Engineering and 03-121 Modern Biology. Pre-med students should register for 03-206. Priority for enrollment will be given to students who have declared the Additional Major in Biomedical Engineering.
Prerequisites: 42-101 and (03-151 or 03-121)
42-300 Junior BME Research Project
Fall and Spring
Research projects for sophomores under the direction of a regular or adjunct BME faculty member. Arrangements may also be made via the Associate Head of BME for off-campus projects provided that a regular or adjunct BME faculty member agrees to serve as a co-advisor. The nature of the project, the number of units, and the criteria for grading are to be determined between the student and the research advisor. The agreement should be summarized in a two-page project description with sign-off by the research advisor and a copy submitted for review and filing with the BME Department. A final written report of the results is required. Units may vary from 9 to 12 according to the expected time commitment, with one unit corresponding to 1 hour of research per week. One (but not more than one) semester of research, if registered for at least 9 units, may be counted as a restricted elective course toward the BME additional major.
42-302 Biomedical Engineering Systems Modeling and Analysis
Fall and Spring: 9 units
This course will prepare students to develop mathematical models for biological systems and for biomedical engineering systems, devices, components, and processes and to use models for data reduction and for system performance analysis, prediction and optimization. Models considered will be drawn from a broad range of applications and will be based on algebraic equations, ordinary differential equations and partial differential equations. The tools of advanced engineering mathematics comprising analytical, computational and statistical approaches will be introduced and used for model manipulation.
Prerequisites: (18-202 or 06-262 or 21-260) and (33-142 or 33-122)
42-341 Introduction to Biomechanics
Fall: 9 units
This course covers the application of solid and fluid mechanics to living tissues. This includes the mechanical properties and behavior of individual cells, the heart, blood vessels, the lungs, bone, muscle and connective tissues as well as methods for the analysis of human motion.
Prerequisites: 24-231 or 12-355 or 06-261
42-400 Senior BME Research Project
Fall and Spring
Research projects for sophomores under the direction of a regular or adjunct BME faculty member. Arrangements may also be made via the Associate Head of BME for off-campus projects provided that a regular or adjunct BME faculty member agrees to serve as a co-advisor. The nature of the project, the number of units, and the criteria for grading are to be determined between the student and the research advisor. The agreement should be summarized in a two-page project description with sign-off by the research advisor and a copy submitted for review and filing with the BME Department. A final written report of the results is required. Units may vary from 9 to 12 according to the expected time commitment, with one unit corresponding to 1 hour of research per week. One (but not more than one) semester of research, if registered for at least 9 units, may be counted as a restricted elective course toward the BME additional major.
42-401 Foundation of BME Design
Fall: 6 units
This course sequence introduces Biomedical Engineering students to the design of useful biomedical products to meet a specific medical need. Students will learn to identify product needs, how to specify problem definitions and to use project management tools. Methods to develop creativity in design will be introduced. The course sequence is comprised of two parts: 42-401 is offered in the Fall semester and provides the students the opportunity to form project teams, select and define a project, create a development plan, and complete an initial prototype. 42-402 is offered in the Spring semester is a full semester course and completes the plan that was developed in the fall semester. This course culminates in the completion of multiple prototypes, a poster presentation, and a written report. Prerequisite: Senior standing in Biomedical Engineering. Co-requisite: 42-101.
Prerequisite: 42-101
42-402 BME Design Project
Spring: 9 units
This course sequence introduces Biomedical Engineering students to the design of useful biomedical products to meet a specific medical need. Students will learn to identify product needs, how to specify problem definitions and to use project management tools. Methods to develop creativity in design will be introduced. The course sequence is comprised of two parts: 42-401 is offered in the Fall semester and provides the students the opportunity to form project teams, select and define a project, create a development plan, and complete an initial prototype. 42-402 is offered in the Spring semester is a full semester course and completes the plan that was developed in the fall semester. This course culminates in the completion of multiple prototypes, a poster presentation, and a written report. Prerequisite: 42-401
42-411 Engineering Biomaterials
Fall: 9 units
This course will cover structure-processing-property relationships in biomaterials for use in medicine. This course will focus on a variety of materials including natural biopolymers, synthetic polymers, and soft materials with additional treatment of metals and ceramics. Topics include considerations in molecular design of biomaterials, understanding cellular aspects of tissue-biomaterials interactions, and the application of bulk and surface properties in the design of medical devices. This course will discuss practical applications of these materials in drug delivery, tissue engineering, biosensors, and other biomedical technologies. Open only to juniors or seniors in CIT, or by permission of instructor.
Prerequisites: 27-215 or 06-221 or 24-221
42-426 Biosensors and BioMEMS
Intermittent: 9 units
This course emphasizes the principles of biomolecule-based sensing, including molecular recognition, biomolecular binding kinetics and equilibrium; methods of detection and signal transduction, including optical, colorimetric, fluorescence, potentiometric, and gravimetric techniques; statistical principles of high throughout screening; microfluidic and microarray device design principles and fabrication technologies; molecular motors. Prerequisites: 03-231 OR 03-232 Biochemistry.
Prerequisite: 03-232
42-431 Introduction to Biomedical Imaging and Image Analysis
Fall: 12 units
This course gives an overview of tools and tasks in various biological and biomedical imaging modalities, such as microscopy, magnetic resonance imaging, x-ray computed tomography, ultrasound and others. Students will be exposed to the major underlying principles in modern imaging systems as well as state of the art methods for processing biomedical images such as deconvolution, registration, segmentation, pattern recognition, etc. The discussion of these topics will draw on approaches from many fields, including physics, statistics, signal processing, and machine learning. As part of the course, students will be expected to complete an independent project. Students will have the opportunity to visit laboratory to see real biomedical imaging devices in action. Prerequisites: 18-290 Signals and Systems or permission of the instructor, working knowledge of Matlab, and some image processing experience. Cross-listed courses: 18-496
Prerequisites: 42-202 and 18-290
42-437 Biomedical Optical Imaging
Fall: 9 units
Biophotonics, or biomedical optics, is a field dealing with the application of optical science and imaging technology to biomedical problems, including clinical applications. The course introduces basic concepts in electromagnetism and light tissue interactions, including optical properties of tissue, absorption, fluorescence, and light scattering. Imaging methods will be described, including fluorescence imaging, Raman spectroscopy, optical coherence tomography, diffuse optical spectroscopy, and photoacoustic tomography. The basic physics and engineering of each imaging technique are emphasized. Their relevance to human disease diagnostic and clinical applications will be included, such as breast cancer imaging and monitoring, 3D retinal imaging, ways of non-invasive tumor detection, as well as functional brain imaging in infants. NOTE: 42-437 is intended for undergraduates only. Pre-requisite: 33-107 Physics II for Engineering Students or permission of the instructor.
Prerequisite: 33-142
42-444 Medical Devices
Fall: 9 units
This course is an introduction to the engineering, clinical, legal and regulatory aspects of medical device performance and failure. Topics covered include a broad survey of the thousands of successful medical devices in clinical use, as well as historical case studies of devices that were withdrawn from the market. In-depth study of specific medical devices will include: cardiovascular medicine, orthopedics, and general medicine. We will study the principles of operation (with hands-on examples), design evolution, and modes of failure. Additional lectures will provide basic information concerning biomaterials used for implantable medical devices (metals, polymers, ceramics) and their biocompatibility, mechanisms of failure (wear, corrosion, fatigue, fretting, etc.). The level of technical content will require junior standing for MCS and CIT students, a degree in science or engineering for non-MCS or non-CIT graduate students, or permission of the instructor for all other students.
42-447 Rehabilitation Engineering
Fall: 9 units
Rehabilitation engineering is the systematic application of engineering sciences to design, develop, adapt, test, evaluate, apply, and distribute technological solutions to problems confronted by individuals with disabilities. This course surveys assistive technologies designed for a variety functional limitations - including mobility, communication, hearing, vision, and cognition - as they apply to activities associated with employment, independent living, education, and integration into the community. This course considers not only technical issues in device development, but also the psychosocial factors and market forces that influence device acceptance by individuals and the marketplace. Open only to students with junior standing who have had at least one engineering class or by permission of instructor.
42-474 Special Topics: Introduction to Biophotonics
Fall: 9 units
Biophotonics, or biomedical optics, is a field dealing with the application of optical science and imaging technology to biomedical problems, including clinical applications. The course introduces basic concepts in electromagnetism and light tissue interactions, including optical properties of tissue, absorption, fluorescence, and light scattering. Imaging methods will be described, including fluorescence imaging, Raman spectroscopy, optical coherence tomography, diffuse optical spectroscopy, and photoacoustic tomography. The basic physics and engineering of each imaging technique are emphasized. Their relevance to human disease diagnostic and clinical applications will be included, such as breast cancer imaging and monitoring, 3D retinal imaging, ways of non-invasive tumor detection, as well as functional brain imaging in infants. NOTE: 42-474 is intended for undergraduates only. Pre-requisite: 33-107 Physics II for Engineering Students or permission of the instructor.
Prerequisite: 33-107
42-612 Tissue Engineering
Spring: 12 units
This course will train students in advanced cellular and tissue engineering methods that apply physical, mechanical and chemical manipulation of materials in order to direct cell and tissue function. Students will learn the techniques and equipment of bench research including cell culture, immunofluorescent imaging, soft lithography, variable stiffness substrates, application/measurement of forces and other methods. Students will integrate classroom lectures and lab skills by applying the scientific method to develop a unique project while working in a team environment, keeping a detailed lab notebook and meeting mandated milestones. Emphasis will be placed on developing the written and oral communication skills required of the professional scientist. The class will culminate with a poster presentation session based on class projects. Pre-requisite: Knowledge in cell biology and biomaterials, or permission of instructor
42-613 Molecular and Micro-scale Polymeric Biomaterials in Medicine
Spring: 9 units
This course will cover aspects of polymeric biomaterials in medicine from molecular principles to device scale design and fabrication. Topics include the chemistry, characterization, and processing of synthetic polymeric materials; cell-biomaterials interactions including interfacial phenomena, tissue responses, and biodegradation mechanisms; aspects of polymeric micro-systems design and fabrication for applications in medical devices. Recent advances in these topics will also be discussed.
42-620 Engineering Molecular Cell Biology
Fall: 12 units
Cells are not only basic units of living organisms but also fascinating engineering systems that exhibit amazing functionality, adaptability, and complexity. Applying engineering perspectives and approaches to study molecular mechanisms of cellular processes plays a critical role in the development of contemporary biology. At the same time, understanding the principles that govern biological systems provides critical insights into the development of engineering systems, especially in the micro- and nano-technology. The goal of this course is to provide basic molecular cell biology for engineering students with little or no background in cell biology, with particular emphasis on the application of quantitative and system perspectives to basic cellular processes. Course topics include the fundamentals of molecular biology, the structural and functional organization of the cell, the cytoskeleton and cell motility, the mechanics of cell division, and cell-cell interactions. Pre-requisites: 21-260 Differential Equations, or 06-262 Mathematical Methods of Chemical Engineering, or 18-202 Mathematical Foundations of Electrical Engineering. Advanced undergraduate or graduate student standing is required. Prior completion of 03-121 Modern Biology is suggested but not required. Proficiency in basic computation such as MATLAB programming is expected.
Prerequisites: 21-260 or 18-202 or 06-262
42-622 Bioprocess Design
Spring: 9 units
This course is designed to link concepts of cell culture, bioseparations, formulation and delivery together for the commercial production and use of biologically-based pharmaceuticals; products considered include proteins, nucleic acids, and fermentation-derived fine chemicals. Associated regulatory issues and biotech industry case studies are also included. The format of the course is a mixture of equal parts lecture, open discussion, and participant presentation. Course work consists of team-oriented problem sets of an open-ended nature and indivudual-oriented industry case studies. The goals of the course work are to build an integrated technical knowledge base of the manufacture of biologically based pharmaceuticals and U.S. biotechnology industry. Working knowledge of cell culture and modern biology, biochemistry and differential equations is assumed. Pre-requisite: 42-321 Cellular and Molecular Biotechnology or both 03-232 Biochemistry and 06-422 Chemical Reaction Engineering, or instructor permission.
Prerequisites: 42-321 or 06-422 or 03-232
42-623 Cellular and Molecular Biotechnology
Fall: 9 units
This course will provide students with an introduction to biotechnology in an engineering context. The focus will be on using microorganisms to prepare therapeutically and technologically relevant biochemicals. Topics to be covered include cellular and microbial metabolism, recombinant DNA methodologies, bioreactor design, protein separation and purification, and systems approaches to biotechnology. Prerequisites: (42-202 Physiology OR 03-121 Modern Biology OR 03-232 Biochemistry) AND (06-262 Mathematical Methods of Chemical Engineering OR 21-260 Differential Equations) OR permission of instructor.
42-624 Biological Transport and Drug Delivery
Spring: 9 units
Analysis of transport phenomena in life processes on the molecular, cellular, organ and organism levels and their application to the modeling and design of targeted or sustained release drug delivery technologies. Coupling of mass transfer and reaction processes will be a consistent theme as they are applied to rates of receptor-mediated solute uptake in cells, drug transport and biodistribution, and drug release from delivery vehicles. Design concepts underlying advances in nanomedicine will be described.
42-630 Introduction to Neuroscience for Engineers
Intermittent: 12 units
The first half of the course will introduce engineers to the neurosciences from the cellular level to the structure and function of the central nervous system (CNS) and include a study of basic neurophysiology; the second half of the course will review neuroengineering methods and technologies that enable study of and therapeutic solutions for diseases or damage to the CNS. A goal of this course is provide a taxonomy of neuroengineering technologies for research or clinical application in the neurosciences.
42-631 Neural Data Analysis
Fall: 9 units
The vast majority of behaviorally relevant information is transmitted through the brain by neurons as trains of actions potentials. How can we understand the information being transmitted? This class will cover the basic engineering and statistical tools in common use for analyzing neural spike train data, with an emphasis on hands-on application. Topics may include neural spike train statistics (Poisson processes, interspike intervals, Fano factor analysis), estimation (MLE, MAP), signal detection theory (d-prime, ROC analysis, psychometric curve fitting), information theory, discrete classification, continuous decoding (PVA, OLE), and white-noise analysis.
42-632 Neural Signal Processing
Fall: 12 units
The brain is among the most complex systems ever studied. Underlying the brain's ability to process sensory information and drive motor actions is a network of roughly 10^11 neurons, each making 10^3 connections with other neurons. Modern statistical and machine learning tools are needed to interpret the plethora of neural data being collected, both for (1) furthering our understanding of how the brain works, and (2) designing biomedical devices that interface with the brain. This course will cover a range of statistical methods and their application to neural data analysis. The statistical topics include latent variable models, dynamical systems, point processes, dimensionality reduction, Bayesian inference, and spectral analysis. The neuroscience applications include neural decoding, firing rate estimation, neural system characterization, sensorimotor control, spike sorting, and field potential analysis. Prerequisites: 18-290; 36-217, or equivalent introductory probability theory and random variables course; an introductory linear algebra course; senior or graduate standing. No prior knowledge of neuroscience is needed.
42-640 Image-Based Computational Modeling and Analysis
Spring: 12 units
Biomedical modeling and visualization play an important role in mathematical modeling and computer simulation of real/artificial life for improved medical diagnosis and treatment. This course integrates mechanical engineering, biomedical engineering, computer science, and mathematics together. Topics to be studied include medical imaging, image processing, geometric modeling, visualization, computational mechanics, and biomedical applications. The techniques introduced are applied to examples of multi-scale biomodeling and simulations at the molecular, cellular, tissue, and organ level scales.
42-643 Microfluids
Intermittent: 12 units
This course offers an introduction to the emerging field of microfluidics with an emphasis on chemical and life sciences applications. During this course students will examine the fluid dynamical phenomena underlying key components of "lab on a chip" devices. Students will have the opportunity to learn practical aspects of microfluidic device operation through hands-on laboratory experience, computer simulations of microscale flows, and reviews of recent literature in the field. Throughout the course, students will consider ways of optimizing device performance based on knowledge of the fundamental fluid mechanics. Students will explore selected topics in more detail through a semester project. Major course topics include pressure-driven and electrokinetically-driven flows in microchannels, surface effects, micro-fabrication methods, micro/nanoparticles for biotechnology, biochemical reactions and assays, mixing and separation, two-phase flows, and integration and design of microfluidic chips. Pre-requisites: 24-231 or 06-261 or 12-355 or instructor permission.
42-645 Cellular Biomechanics
Intermittent: 9 units
This course discusses how mechanical quantities and processes such as force, motion, and deformation influence cell behavior and function, with a focus on the connection between mechanics and biochemistry. Specific topics include: (1) the role of stresses in the cytoskeleton dynamics as related to cell growth, spreading, motility, and adhesion; (2) the generation of force and motion by moot molecules; (3) stretch-activated ion channels; (4) protein and DNA deformation; (5) mechanochemical coupling in signal transduction. If time permits, we will also cover protein trafficking and secretion and the effects of mechanical forces on gene expression. Emphasis is placed on the biomechanics issues at the cellular and molecular levels; their clinical and engineering implications are elucidated. 3 hrs. lec. Prerequisite: Instructor permission. Prerequisites: None. Corequisites: None. Cross Listed Courses: 24-655 Notes: None. Reservations:
42-646 Molecular Biomechanics
Intermittent: 9 units
This class is designed to present concepts of molecular biology, cellular biology and biophysics at the molecular level together with applications. Emphasis will be placed both on the biology of the system and on the fundamental physics, chemistry and mechanics which describe the molecular level phenomena within context. In addition to studying the structure, mechanics and energetics of biological systems at the nano-scale, we will also study and conceptually design biomimetic molecules and structures. Fundamentals of DNA, globular and structured proteins, lipids and assemblies thereof will be covered.
42-647 Continuum Biomechanics: Solid and Fluid Mechanics of Physiological Systems
Spring: 12 units
This course provides a general survey of the solid and fluid mechanics of physiological systems, within the framework of continuum mechanics. The main objective of the course is to understand mathematical modeling of solid materials such as bone and tissues, and fluid mechanics of blood and other biofluids such as synovial fluid, etc. The course as a whole encourages class participation and discussion in a seminar-type fashion. The course begins with a historical review of the subject followed by a review of vector and tensor analysis, before discussing various measures of deformation and stress formulations. The development and understanding of appropriate constitutive models for particular problems are at the core of this course. Both analytical and to some extent experimental results are presented through readings from reports in recent journals and the relevance of these results to the solution of unsolved problems is highlighted. The intent is to provide the basic ideas of continuum mechanics for engineering and science students with little or no background in biomechanics or mathematical modeling, with particular emphasis on the application of quantitative and system perspectives to fluid and solid mechanics problems. In addition to looking at various examples with physiological applications, the last few weeks of the course are dedicated to discussing individually-crafted research projects for the students.
42-648 Cardiovascular Mechanics
Spring: 12 units
The primary objective of the course is to learn to model blood flow and mechanical forces in the cardiovascular system. After a brief review of cardiovascular physiology and fluid mechanics, the students will progress from modeling blood flow in a.) small-scale steady flow applications to b.) small-scale pulsatile applications to c.) large-scale or complex pulsatile flow applications. The students will also learn how to calculate mechanical forces on cardiovascular tissue (blood vessels, the heart) and cardiovascular cells (endothelial cells, platelets, red and white blood cells), and the effects of those forces. Lastly, the students will learn various methods for modeling cardiac function. When applicable, students will apply these concepts to the design and function of selected medical devices (heart valves, ventricular assist devices, artificial lungs).
42-661 Surgery for Engineers
Spring: 9 units
This course explores the impact of engineering on surgery. Students will interact with clinical practitioners and investigate the technological challenges that face these practitioners. A number of visits to the medical center are anticipated for hands on experience with a number of technologies utilized by surgeons to demonstrate the result of advances in biomedical engineering. These experiences are expected to include microvascular surgery, robotic surgery, laparoscopic, and endoscopic techniques. Tours of the operating room and shock trauma unit will be arranged. If possible observation of an operative procedure will be arranged (if scheduling permits). Invited surgeons will represent disciplines including cardiovascular surgery, plastic and reconstructive surgery, surgical oncology, trauma surgery, minimally invasive surgery, oral and maxillofacial surgery, bariatric surgery, thoracic surgery, orthopedic surgery, and others. The Primary Instructor is Howard Edington, M.D., MBA System Chairman of Surgery, Allegheny Health Network. This course meets once a week for 3 hours. Several sessions will be held at the Medical Center, transport provided. Pre-requisite: Physiology 42-202 and one of the introductory engineering courses, 42-101, 06-100, 12-100. 18-100, 19-101, 24-101, or 27-100
42-663 Computational Methods in BME
Spring: 12 units
This goal of this course is to enable students with little or no programming background to solve simple computational problems in science and engineering. Emphasis will be placed on enabling students to use currently available numerical methods (rather than developing anew) to solve engineering problems. Upon completing the course, the successful student will be able to use basic knowledge regarding computer architecture, data types, binary arithmetic, and programming, to solve sample quantitative problems in engineering. Topics will include: solving linear systems of equations, model fitting using least squares techniques (linear and nonlinear), data interpolation, numerical integration and differentiation, solving differential equations, and data visualization. Specific example computations in each topic above will be drawn from problems in physics, chemistry, as well as signal and image processing, and biomedical engineering. Students will work independently in groups for a final project. Matlab will be used as the programming language/environment for this class, although different languages such as C, Java, and Python will be briefly discussed (time permitting). May count as practicum for practicum-option MS. Pre-requisite: Calculus, multivariate calculus, linear algebra, and differential equations
42-664 Bioinstrumentation
Intermittent: 9 units
This course aims to build the foundation of basic principles, applications and design of bioinstrumentation. Topics covered include biosignals recording, transducers for biomedical application, action potentials EMG, EEG, ECG, amplifiers and signal processing, blood flow and pressure measurements, data acquisition and signal conditioning, spectral analysis of data, filtering, and safety aspects of electrical measurements. Ultimately, students will learn (1) how to apply basic circuit theory to perform measurement of biosignals, (2) be familiar and use common measurement devices, such as multimeter and oscilloscope, (3) be familiar with Op-amps circuits, (4) how to acquire and analyze a signal using time and frequency techniques, and (5) how to filter a signal to remove noise. Pre-requisite: Physics II (E&M)
42-670 Special Topics: Biomaterial Host Interactions in Regenerative Medicine
Fall: 12 units
Special Topics: This course will provide students with hands-on experience in investigating host responses to synthetic and naturally biomaterials used in regenerative medicine applications. Students will gain experience in the analysis of host responses to these biomaterials as well as strategies to control host interaction. Biomaterial biocompatibility, immune interactions, tissue healing and regeneration will be addressed. Students will integrate classroom lectures with laboratory skills evaluating host-material interactions in a laboratory setting. Laboratory characterization techniques will include cell culture techniques, microscopic, cytochemical, immunocytochemical and histological analyses. Prerequisite: junior or senior standing in Biomedical Engineering or consent of the instructor.
42-671 Precision Medicine for Biomedical Engineers
Fall: 9 units
This course explores the opportunities for engineers in precision medicine of complex medical disorders. Students will interact with clinical practitioners and investigate the technological challenges that face these practitioners. The course will focus on common complex conditions and diseases such as inflammatory bowel disease (IBD), pancreatitis, diabetes mellitus and obesity, rheumatoid arthritis, multiple sclerosis, pain syndrome and pharmacogenetics. Improvement in care of these conditions requires a reverse engineering approach, and new tools because of the complexity and unpredictability of clinical course and best treatments on a case-by-case basis. Currently, the cost of medications for these conditions in Pittsburgh alone is >1 billion, with a large percent of patients receiving less than optimal treatment because of lack of precision medicine tools. The course includes introduction to medical genetics, biomarkers of disease, health records, disease modeling, outcome predictions, therapies, remote monitoring and smart applications. Special lectures on health economics and career opportunities are also planned. Each session will include didactic lectures, workshops and development of applications. Specific engineering topics which may be relevant to each of these specialties as well as topics which span many specialties (for example biodetectors, computational biology, bioinformatics, UI/UX, gaming ideas to connect patients to products, integrated applications) will be presented by various faculty members of the CMU biomedical engineering and other dept. and UPMC/UPitt faculty. Students will gain experience exploring genetic variants associated with common diseases, including the opportunity to explore their own DNA. Instructors: David C. Whitcomb, MD, PhD (UPMC) Philip Empey, PharmD, PhD (UPMC)
42-672 Fundamentals of Biomedical Imaging and Image Analysis
Spring: 12 units
This course introduces fundamentals of biological and medical imaging modalities and related image analysis techniques. It is organized into three units. The first unit introduces fundamental principles of biological imaging modalities, such as fluorescence microscopy, super-resolution microscopy, and electron microscopy. These modalities are used to visualize and record biological structures and processes at the molecular and cellular levels. The second unit introduces fundamental principles of imaging modalities, such as magnetic resonance imaging, x-ray computed tomography, and ultrasound. These modalities are used to visualize and record medical structures and processes at the tissue and organ levels. Recent developments in convergence of biological and medical imaging are briefly discussed. The third section introduces fundamentals of computational techniques used for analyzing and understanding biological and medical images, such as deconvolution, registration, segmentation, tracking, and pattern recognition. The introduction to these topics will draw on concepts and techniques from several related fields, including physics, statistics, signal processing, computer vision, and machine learning. As part of the course, students will complete several independent projects. Students will also have the opportunity to visit laboratories to see some of the actual biomedical imaging devices in action. Prerequisites: 18-290 Signals and Systems or permission of the instructor. Proficiency in basic programming is expected. Knowledge of image processing, computer vision, and/or MATLAB is helpful but not essential.
42-673 Special Topics: Stem Cell Engineering
Intermittent: 9 units
Special Topics: This course will give an overview over milestones of stem cell research and will expose students to current topics at the frontier of this field. It will introduce students to the different types of stem cells as well as environmental factors and signals that are implicated in regulating stem cell fate. The course will highlight techniques for engineering of stem cells and their micro-environment. It will evaluate the use of stem cells for tissue engineering and therapies. Emphasis will be placed on discussions of current research areas and papers in this rapidly evolving field. Students will pick a class-related topic of interest, perform a thorough literature search, and present their findings as a written report as well as a paper review and a lecture. Lectures and discussions will be complemented by practical lab sessions, including: stem cell harvesting and culture, neural stem cell transfection, differentiation assays, and immunostaining, polymeric microcapsules as advanced culture systems, and stem cell integration in mouse brain tissue. The class is designed for graduate students and upper undergraduates with a strong interest in stem cell biology, and the desire to actively contribute to discussions in the class.
42-674 Special Topics: Engineering for Survival: ICU Medicine
Intermittent: 9 units
Special Topics: Engineering for Survival: ICU Medicine The overall learning objective of this class is to expose students to acute care medicine and the fundamentals of acute illness. The lectures review the structure and function of different body systems. Typical modes of failure (disease) are then described and illustrated with examples using actual de-identified cases based on over 30 years of experiences in the intensive care unit (ICU) by Dr. Rosenbloom. Field trips are made to a local critical care and emergency medicine simulation facility at the University of Pittsburgh. An optional opportunity to participate in ICU rounds is also available. Requirements: Junior standing and higher
42-676 Bio-nanotechnology: Principles and Applications
Fall: 9 units
"Have you ever wondered what is nanoscience and nanotechnology and their impact on our lives? In this class we will go through the key concepts related to synthesis (including growth methodologies and characterizations techniques) and chemical/physical properties of nanomaterials from zero-dimensional (0D) materials such as nanoparticles or quantum dots (QDs), one-dimensional materials such as nanowires and nanotubes to two-dimensional materials such as graphene. The students will then survey a range of biological applications of nanomaterials through problem-oriented discussions, with the goal of developing design strategies based on basic understanding of nanoscience. Examples include, but are not limited to, biomedical applications such as nanosensors for DNA and protein detection, nanodevices for bioelectrical interfaces, nanomaterials as building blocks in tissue engineering and drug delivery, and nanomaterials in cancer therapy."
42-698 Special Topics
Fall and Spring: 9 units
42-698A Bioinstrumentation (Spring), 42-698C Introduction to Biomedical Signal Processing (Fall) 42-698D Engineering in Medicine (Fall), 42-698E Surgery for Engineers (Spring), 42-698G Molecular and Micro-scale Polymeric Biomaterials in Medicine (Spring), 42-698H BME Systems Modeling and Analysis (Fall), 42-698I Biofluid Mechanics (Fall), and 42-698P Introduction to Biophotonics (Fall) Please see http://www.bme.cmu.edu/ugprog/catalog.html for detailed course descriptions.
42-699 Special Topics
Fall and Spring: 12 units
42-699G Computational Methods in Biomedical Engineering (Spring), 42-699L Inventive Problem Solving in Biomedical Engineering (Fall), 42-699N Applied Nanoscience and Nanotechnology (Fall), and 42-699P Introduction to Biophotonics (Fall) Please see http://www.bme.cmu.edu/ugprog/catalog.html for detailed course descriptions.
42-713 Applied Nanoscience and Nanotechnology
Fall and Spring: 12 units
Have you ever wondered what is nanoscience and nanotechnology and their impact on our lives? In this class we will go through the key concepts related to synthesis (including growth methodologies and characterizations techniques) and chemical/physical properties of nanomaterials from zero-dimensional (0D) materials such as nanoparticles or quantum dots (QDs), one-dimensional materials such as nanowires and nanotubes to two-dimensional materials such as graphene. The students will then survey a range of applications of nanomaterials through problem-oriented discussions, with the goal of developing design strategies based on basic understanding of nanoscience. Examples include, but are not limited to, biomedical applications such as nanosensors for DNA and protein detection, nanodevices for bioelectrical interfaces, nanomaterials as building blocks in tissue engineering and drug delivery, and nano materials in cancer therapy. Pre-requisite: Graduate standing. College level chemistry or physical chemistry, and thermodynamics.
42-735 Medical Image Analysis
Spring: 12 units
Students will gain theoretical and practical skills in medical image analysis, including skills relevant to general image analysis. The fundamentals of computational medical image analysis will be explored, leading to current research in applying geometry and statistics to segmentation, registration, visualization, and image understanding. Student will develop practical experience through projects using the National Library of Medicine Insight Toolkit ( ITK ), a popular open-source software library developed by a consortium of institutions including Carnegie Mellon University and the University of Pittsburgh. In addition to image analysis, the course will include interaction with clinicians at UPMC. It is possible that a few class lectures may be videoed for public distribution. Prerequisites: Knowledge of vector calculus, basic probability, and either C++ or python. Required textbook, "Machine Vision", ISBN: 052116981X; Optional textbook, "Insight to Images", ISBN: 9781568812175.
Prerequisite: 03-121
Course Website: http://www.cs.cmu.edu/~galeotti/methods_course/
42-737 Biomedical Optical Imaging
Fall: 12 units
Biophotonics, or biomedical optics, is a field dealing with the application of optical science and imaging technology to biomedical problems, including clinical applications. The course introduces basic concepts in electromagnetism and light tissue interactions, including optical properties of tissue, absorption, fluorescence, and light scattering. Imaging methods will be described, including fluorescence imaging, Raman spectroscopy, optical coherence tomography, diffuse optical spectroscopy, and photoacoustic tomography. The basic physics and engineering of each imaging technique are emphasized. Their relevance to human disease diagnostic and clinical applications will be included, such as breast cancer imaging and monitoring, 3D retinal imaging, ways of non-invasive tumor detection, as well as functional brain imaging in infants.
42-772 Special Topics: Applied Nanoscience and Nanotechnology
Fall: 12 units
Have you ever wondered what is nanoscience and nanotechnology and their impact on our lives? In this class we will go through the key concepts related to synthesis (including growth methodologies and characterizations techniques) and chemical/physical properties of nanomaterials from zero-dimensional (0D) materials such as nanoparticles or quantum dots (QDs), one-dimensional materials such as nanowires and nanotubes to two-dimensional materials such as graphene. The students will then survey a range of applications of nanomaterials through problem-oriented discussions, with the goal of developing design strategies based on basic understanding of nanoscience. Examples include, but are not limited to, biomedical applications such as nanosensors for DNA and protein detection, nanodevices for bioelectrical interfaces, nanomaterials as building blocks in tissue engineering and drug delivery, and nano materials in cancer therapy. Pre-requisite: Graduate standing. College level chemistry or physical chemistry, and thermodynamics.
42-773 Special Topics: Inventive Problem Solving in Biomedical Engineering
Fall: 12 units
This course is aimed at discovering inventive solutions to some of medicines most difficult problems. It involves a theory of inventive problem solving known as Triz that teaches the student how to invent on demand. The structure of the course will follow a flipped classroom model: with reading assignments and pre-recorded lectures assigned before class and homework performed in-class. This will allow students to learn the material at their own pace, and to translate theory to practice in a group setting with mentorship of the course instructor and teaching assistant, and teamwork of classmates. Throughout the semester, specific problems will be assigned to the entire class on topics emphasizing cost saving (affordable health care act), medicine for under-resourced settings, and global health. A final project will be required of each student on a topic of choice (with instructor approval.) Each project will have an associated client from industry or healthcare who will serve as outside reviewer. The composition of the class will emphasize biomedical engineering students, but will also invite a limited enrollment of students from the School of Design, Tepper, and Heinz. Accordingly, there will be emphasis on multi-disciplinary teamwork, and networking. In summary, the goals of this course are to: develop formal skills in inventive problem solving, gain proficiency in teamwork and networking, and to actually solve real-world problems in medicine. May count as practicum for practicum-option MS. Pre-requisite: Graduate standing for MCS and CIT students. For non-MCS or CIT graduate students, a degree in a science or engineering. For all other students, permission of the instructor.
42-774 Special Topics: Introduction to Biophotonics
Fall: 12 units
Biophotonics, or biomedical optics, is a field dealing with the application of optical science and imaging technology to biomedical problems, including clinical applications. The course introduces basic concepts in electromagnetism and light tissue interactions, including optical properties of tissue, absorption, fluorescence, and light scattering. Imaging methods will be described, including fluorescence imaging, Raman spectroscopy, optical coherence tomography, diffuse optical spectroscopy, and photoacoustic tomography. The basic physics and engineering of each imaging technique are emphasized. Their relevance to human disease diagnostic and clinical applications will be included, such as breast cancer imaging and monitoring, 3D retinal imaging, ways of non-invasive tumor detection, as well as functional brain imaging in infants. Pre-requisite: Graduate standing. College level physics covering electromagnetism and optics or permission of the instructor.

Full-Time Faculty

ABBOTT, ROSALYN, Assistant Professor of Biomedical Engineering – Ph.D., University of Vermont, 2011;

ARMITAGE, BRUCE A. , Professor of Chemistry, Biological Sciences, and Biomedical Engineering – Ph.D., University of Arizona, 1993;

BARTH, ALISON L., Professor, Biological Sciences, and Biomedical Engineering – Ph.D., UC Berkeley, 1997;

BEHRMANN, MARLENE, George A. and Helen Dunham Cowan Professor of Cognitive Neuroscience Center for the Neural Basis of Cognition and Department of Psychology Professor, Biomedical Enegineering – Ph.D., University of Toronto, 1991;

BETTINGER, CHRISTOPHER J. , Associate Professor of Biomedical Engineering and Materials Science & Engineering – Ph.D., Massachusetts Institute of Technology, 2008;

BRUCHEZ, MARCEL P. , Associate Professor of Biological Sciences, Chemistry, and Biomedical Engineering – Ph.D., University of California, Berkeley, 1998;

CAI, YANG, Senior Systems Scientist, CyLab, Associate Research Professor, Biomedical Engineering – Ph.D., West Virginia University, 1997;

CHAMANZAR, MAYSAM , Assistant Professor, Electrical and Computer Engineering, Biomedical Engineering – Ph.D., Georgia Institute of Technology, 2012;

CAMPBELL, PHIL G. , Research Professor, Institute of Complex Engineering Systems, Biomedical Engineering, Biological Sciences, Materials Science & Engineering – Ph.D., The Pennsylvania State University, 1985;

CHASE, STEVEN M., Associate Professor of Biomedical Engineering and Center for the Neural Basis of Cognition – Ph.D., Johns Hopkins University, 2006;

CHOSET, HOWIE, Professor, Robotics Institute, Biomedical Engineering, and Electrical & Computer Engineering – Ph.D., California Institute of Technology , 1996;

COHEN-KARNI, TZAHI (ITZHAQ), Assistant Professor of Biomedical Engineering and Materials Science & Engineering – Ph.D., Harvard, 2011;

COOK, KEITH, Professor and Associate Department Head of Graduate Studies of Biomedical Engineering – Ph.D., Northwestern University, 2000;

DAHL, KRIS N., Professor of Chemical Engineering, Biomedical Engineering, and Materials Science & Engineering – Ph.D., University of Pennsylvania, 2004;

DOMACH, MICHAEL M. , Professor of Chemical Engineering and Biomedical Engineering – Ph.D., Cornell University, 1983;

FEDDER, GARY K., Howard M. Wilkoff Professor, Institute for Complex Engineering Systems, Biomedical Engineering, Electrical & Computer Engineering, Robotics Institute – Ph.D., University of California, Berkeley, 1994;

FEINBERG, ADAM W., Associate Professor of Biomedical Engineering and Materials Science & Engineering – Ph.D., University of Florida, 2004;

GALEOTTI, JOHN, Systems Scientist, Robotics Institute and Assistant Professor of Biomedical Engineering – Ph.D, Carnegie Mellon University, 2007;

GEYER, HARMUT, Associate Professor, Robotics Institute and Biomedical Engineering – Ph.D., Friedrich-Schiller-University of Jena, Germany, 2005 ;

GITTIS, ARYN, Associate Professor, Biological Sciences, and Biomedical Engineering – Ph.D., University of California, 2008;

GROVER, PULKIT, Assistant Professor, Electrical & Computer Engineering, Center for Neural Basis of Cognition, and Biomedical Engineering – Ph.D., UC Berkeley, 2010;

HE, BIN, Department Head, Biomedical Engineering; Professor of Biomedical Engineering, Electrical & Computer Engineering, and Center for Neural Basis of Cognition – Ph.D., Tokyo Institute of Technology, 1988;

HO, CHIEN , Professor of Biological Sciences and Biomedical Engineering – Ph.D., Yale University, 1961;

HOLLINGER, JEFFREY O. , Professor Emeritus of Biomedical Engineering and Biological Sciences – D.D.S. and Ph.D., University of Maryland, 1973 & 1981;

KAINERSTORFER, JANA M., Assistant Professor of Biomedical Engineering – Ph.D., University of Vienna, 2010;

KASS, ROBERT, Maurice Falk Professor, Statistics, Department of Machine Learning, Center for the Neural Basis of Cognition, and Biomedical Engineering Interim co-Director, Center for the Neural Basis of Cognition – Ph.D., University of Chicago, 1980;

KELLY, SHAWN, Adjunct Assistant Professor of Biomedical Engineering – Ph.D., Massachusetts Institute of Technology, 2003;

KUHLMAN, SANDRA , Assistant Professor, Biological Sciences, and Biomedical Engineering – Ph.D., University of Kentucky, 2001;

LEDUC, PHILIP R., Professor of Mechanical Engineering, Biomedical Engineering, and Biological Sciences – Ph.D., Johns Hopkins University, 1999;

LOESCHE, MATHIAS , Professor of Physics and Biomedical Engineering – Ph.D., Technical University of Munich, 1986;

MAJIDI, CARMEL, Associate Professor of Mechanical Engineering and Biomedical Engineering – Ph.D., University of California, Berkeley; Carnegie Mellon, 2007–

MCHENRY , MICHAEL E. , Professor of Materials Science & Engineering and Biomedical Engineering – Ph.D., Massachusetts Institute of Technology, 1988;

MINDEN, JONATHAN S. , Professor of Biological Sciences and Biomedical Engineering – Ph.D., Albert Einstein College of Medicine, 1985;

MOURA , JOSE M. F., Professor of Electrical & Computer Engineering and Biomedical Engineering – Ph.D., Massachusetts Institute of Technology, 1975;

MURPHY, ROBERT F., Ray and Stephanie Lane Professor of Computational Biology and Professor of Biological Sciences, Biomedical Engineering, and Machine Learning – Ph.D., California Institute of Technology, 1980;

OZDOGANLAR, BURAK , Associate Professor of Mechanical Engineering, Biomedical Engineering and Materials Science & Engineering – Ph.D., University of Michigan, 1999;

RABIN, YOED, Professor of Mechanical Engineering and Biomedical Engineering – D.Sc., Technion - Israel Institute of Technology, 1994;

REN, XI (CHARLIE), Assistant Professor of Biomedical Engineering – Ph.D., Peking University, 2011;

RIVIERE, CAMERON N., Associate Research Professor, Robotics Institute and Biomedical Engineering – Ph.D., Johns Hopkins University, 1995;

RUSSELL, ALAN J., Highmark Distinguished Career Professor, Institute of Complex Engineering Systems and Biomedical Engineering – Ph.D., University of London, 1987;

SCHNEIDER, JAMES W., Professor of Chemical Engineering and Biomedical Engineering – Ph.D., University of Minnesota, 1998;

SHIMADA, KENJI, Theodore Ahrens Professor in Engineering – Ph.D., Massachusetts Institute of Technology, 1993;

SIMKO (PALCHESKO), RACHELLE, Special Faculty - Researcher – Ph.D., Duquesne University, 2011;

SYDLIK, STEFANIE, Assistant Professor of Chemistry and Biomedical Engineering – Ph.D., Massachusetts Institute of Technology, 2012;

TAYLOR, REBECCA, Ph.D. – Assistant Professor of Mechanical Engineering and Biomedical Engineering, Stanford University, 2013;

TILTON, ROBERT D. , Professor of Biomedical Engineering and Chemical Engineering – Ph.D., Stanford University, 1991;

TRUMBLE, DENNIS, Adjunct Assistant Professor of Biomedical Engineering (on campus) – Ph.D., Carnegie Mellon University, 2010;

WANG, YU-LI, Mehrabian Professor of Biomedical Engineering – Ph.D., Harvard University, 1980;

WASHBURN, NEWELL R. , Associate Professor of Biomedical Engineering, Chemistry, and Materials Science & Engineering – Ph.D., University of California, Berkeley, 1998;

WEISS, LEE E., Research Professor, Robotics Institute, Biomedical Engineering, and Materials Science & Engineering – Ph.D., Carnegie Mellon University, 1984;

WHITEHEAD, KATHRYN A, Associate Professor of Chemical and Biomedical Engineering – Ph.D., University of California, Santa Barbara, 2007;

YANG, GE, Associate Professor, Biomedical Engineering and Lane Center for Computational Biology – Ph.D., University of Minnesota, 2004;

YTTRI, ERIC, Assistant Professor, Biological Sciences, Center for the Nneural Basis of Cognition, Biomedical Engineering – Ph.D., Washington University in St Louis, 2011;

YU, BYRON, Associate Professor of Biomedical Engineering and Electrical & Computer Engineering – Ph.D., Stanford University, 2007;

ZAPANTA, CONRAD M., Teaching Professor and Associate Head of Undergraduate Education of Biomedical Engineering – Ph.D., The Pennsylvania State University, 1997;

ZHANG, YONGJIE JESSICA, Associate Professor of Mechanical Engineering and Biomedical Engineering – Ph.D., University of Texas at Austin, 2005;